ea0034p273 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014
Challis B G
, Harris J
, Sleigh A
, Orme S M
, Seevaratnam N
, Dhatariya K
, Simpson H L
, Semple R K
Glucokinase (GCK) serves as the blood glucose sensor in pancreatic β-cells, being critically involved in transducing elevated blood glucose into increased insulin secretion. Inactivating GCK mutations cause a subtype of maturity onset diabetes of the young (MODY), whereas activating mutations are a rare cause of hyperinsulinaemic hypoglycaemia, usually presenting in infancy.We now describe the case of a 60-year-old woman who first presen...